Institute Of Nanotechnology Scientists Formulate Nanoparticle
Scientists at the Institute of Nanotechnology an autonomous institute at the Government of India's Department of Science and Technology Mohali, have manufactured nanoparticles with chitosan and used these nanoparticles with zinc gluconate to reduce the severity of rheumatoid arthritis. Element zinc is important for maintaining normal bone homeostasis, and its levels are reported to decrease rheumatoid in patients. It is also known that oral supplementation of zinc as zinc gluconate has very low bioavailability in humans. Chitosan, a biocompatible, biodegradable natural polysaccharide that is one of the most abundant biopolymers derived from the exoskeleton of crustaceans, has shown absorption promoting characteristics. The INST team has specifically chosen chitosan because it is biodegradable, biocompatible, non-toxic and mucoadhesive in nature. A previously published report in the journal 'Magnesium Research' demonstrated that after intraperitoneal administration in mice, zinc oxide in standard form resulted in a slight increase in serum zinc levels, while higher serum zinc levels in nano form significantly developed Bioavailability. In recent times, the ionic gel method has been widely employed to make chitosan nanoparticles, which may contain various pharmacologically active pharmacological agents. DST-Science and Engineering Research Board (SERB) and DST-Nanomission supported the study, led by Rehan Khan, published in the journal ACS Biomaterials Science and Engineering, analyzed the superior efficacy of zinc gluconate loaded chirosan nanoparticles in the free form of zinc gluconate. The team prepared gelate gluconate loaded chitosan nanoparticles in double distilled water using chitosan and sodium tripolyphosphate and zinc gluconate was added along with synthesis of chitosan nanoparticles. Nanoparticles were characterized for various physico chemical properties, and then the anti arthritic potential was investigated against collagen induced arthritis in Wistar rats. They observed that treatment of mice with zinc gluconate and zinc gluconate loaded chitosan nanoparticles reduced the severity of arthritis by reducing joint inflammation, erythema, and edema but zinc gluconate loaded nanoparticles demonstrated better efficacy. The team assessed various parameters such as biochemical analysis, histological observation, and immunological expression of inflammatory markers and suggested that zinc gluconate-loaded chitosan nanoparticles had better therapeutic effect than the free form of zinc gluconate. inflammatory potential of zinc gluconate-loaded chitosan nanoparticles.